Barry Horwitz, Ph.D.

SECTION ON BRAIN IMAGING & MODELING

NIHBC 10 - CLINICAL CENTER BG RM 7N240 10 CENTER DR BETHESDA MD 20892

MSC:

1635

Phone:

+1 301 594 7755

Email:

horwitzb@nidcd.nih.gov

Scientist Emeritus (Brain Imaging and Modeling)
Voice, Speech, and Language Branch

Dr. Horwitz received his B.A. degree from Washington University in St. Louis, and his Ph.D. in physics from the University of Pennsylvania. After several years of teaching physics, he joined the National Institute on Aging as a senior staff fellow in the Laboratory of Neurosciences, headed by Stanley I. Rapoport. Dr. Horwitz's work focused on developing methods for using positron emission tomography and other functional neuroimaging data to determine how different brain regions interact in human subjects.

In 1989, he obtained tenure, and in 1999 he joined the Language Section, NIDCD, as a senior investigator. In 2002, he became chief of the Brain Imaging and Modeling Section of the NIDCD. Until Dr. Horwitz's retirement in 2017, his laboratory studied the neural basis of human cognition, especially auditory and language function, using functional brain imaging and computational neural modeling.

Laboratory:

Voice, Speech, and Language Branch

Scientific Areas:

Neuromodeling, functional brain imaging, and language.

Selected Publications

Liu, Q., Ulloa, A., Horwitz, B.: Using a large-scale neural model of cortical object processing to investigate the neural substrate for managing multiple items in short-term memory, J Cogn Eurosci 1-17, doi: 10.1162/jocn_a_01163, 2017.
Ulloa, A., Horwitz, B.: Embedding task-based neural models into a connectome-based model of the cerebral cortex, Front Neuroinform 3;10:32, doi: 10.3389/fninf.2016.00032, 2016.
Xu, B., Sandrini, M., Wang, W.T., Smith, J.F., Sarlls, J.E., Awosika, O., Butman, J.A., Horwitz, B., Cohen, L.G.: PreSMA stimulation changes task-free functional connectivity in the fronto-basal-ganglia that correlates with response inhibition efficiency, Hum Brain Mapp 37(9):3236-49, doi: 10.1002/hbm.23236, 2016.
Coderre, E.L., Smith, J.F., van Heuven, W.J., Horwitz, B.: The functional overlap of executive control and language processing in bilinguals, Bilingualism 19(3):471-488, doi: 10.1017/S1366728915000188, 2016.
Ard, T., Carver, F.W., Holroyd, T., Horwitz, B., Coppola, R.: Detecting functional connectivity during audiovisual integration with MEG: A comparison of connectivity metrics, Brain Connectivity 5: 336-348, 2015.
Fuertinger, S., Horwitz, B., Simonyan, K.: The functional connectome of speech control, PloS Biology 13: e1002209. doi:10.1371/journal.pbio.1002209, 2015.
Kikuchi, Y., Horwitz, B., Mishkin, M., Rauschecker, J.P.: Processing of harmonics in the lateral belt of macaque auditory cortex, Frontiers in Neuroscience 8: 204, doi: 10.3389/fnins.2014.00204. 2014.
Horwitz, B., Simonyan, K.: PET neuroimaging: Plenty of studies still need to be performed, NeuroImage 84: 1101-1103, 2014.
Horwitz, B., Hwang, C., Alstott, J.: Interpreting the effects of altered brain anatomical connectivity on functional connectivity: A role for computational neural modeling, Frontiers in Human Neuroscience 7: 649, doi: 10.3389/fnhum.2013.00649, 2013.
Smith, J.F., Braun, A.R., Alexander, A.E., Chen, K. Horwitz, B.: Separating lexical-semantic access from other mnemonic processes in picture-name verification, Fron. Lang. Sci. 4: 706, doi:10.3389/fpsyg.2013.00706, 2013.
Banerjee, A., Horwitz, B.: Can quantum probability help analyze the behavior of functional brain networks?, Beh. Brain Sci. 36: 278-279, 2013.
Smith, J.F., Chen, K., Pillai, A.S., Horwitz, B.: Identifying effective connectivity parameters in simulated fMRI: A direct comparison of switching linear dynamic system, stochastic dynamic causal, and multivariate autoregressive models, Frontiers Brain Imaging Methods 7: 70, doi: 10.3389/fnins.2013.00070, 2013.
Gilbert, J.R., Pillai, A.S., Horwitz, B.: Assessing crossmodal matching of abstract auditory and visual stimuli in posterior superior temporal sulcus with MEG, Brain and Cognition 82: 161-170, 2013.
Simonyan, K., Herscovitch, P., Horwitz, B.: Speech-induced striatal dopamine release is left lateralized and coupled to functional striatal circuits in healthy humans: A combined PET, fMRI and DTI study, Neuroimage, 70: 21-32, 2013.
Pillai, A.S., Gilbert, J.R., Horwitz, B: Early sensory cortex is activated in the absence of explicit input during crossmodal item retrieval: Evidence from MEG, Beh. Brain Res. 238: 265-272, 2013.
Husain, F.T., Patkin, D.J., Kim, J., Braun, A.R., Horwitz, B.: Dissociating neural correlates of meaningful emblems from meaningless gestures in deaf signers and hearing non-signers, Brain Research 1478: 24-35, 2012.
Simonyan, K., Horwitz, B., Jarvis, E.D.: Dopamine regulation of human speech and bird song: A critical review, Brain and Language 122: 142-150, 2012.
Horwitz, B., Banerjee, A.: A role for neural modeling in the study of brain disorders, Frontiers Syst. Neurosci. 6: 57, doi: 10.3389/fnsys.2012.00057, 2012.
Banerjee, A., Pillai, A.S., Sperling, J.R., Smith, J.F., Horwitz, B.: Temporal microstructure of cortical networks (TMCN) underlying task-related differences, Neuroimage 62: 1643-1657, 2012.
Lowell, S.Y., Reynolds, R.C., Chen, G., Horwitz, B., Ludlow, C.L.: Functional connectivity and laterality of the motor and sensory components in the volitional swallowing network, Exp. Brain Res. 219: 85-96, 2012.
Horwitz, B., Horovitz, S.G. Introduction to special topic - brain connectivity analysis: investigating brain disorders. Part 1: The review articles. Frontiers in Syst. Neurosci. 6: 3, doi:10.3389/fnsys.2012.00003, 2012.
Smith, J.F., Pillai, A.S., Chen, K., Horwitz, B. Effective connectivity modeling for fMRI: Six issues and possible solutions using linear dynamic systems. Frontiers in Syst. Neurosci. 5: 104, doi: 10.3389/fnsys.2011.00104, 2012.
Banerjee, A., Pillai, A.S., Horwitz, B. Using large-scale neural models to interpret connectivity measures of cortico-cortical dynamics at millisecond temporal resolution. Frontiers in Syst. Neurosci 5: 102, doi: 10.3389/fnsys.2011 .00102, 2012.
Horwitz, B., Rowe, J.B. Functional biomarkers for neurodegenerative disorders based on the network paradigm. Prog. Neurobiol. 95: 505-509, 2011.
Husain, F.T., Pajor, N.M., Smith, J.F., Kim, H.J., Rudy, S., Zalewski, C., Brewer, C., Horwitz, B.Discrimination task reveals differences in neural bases of tinnitus and hearing impaiment.PLOS One 6: e26639. doi:10.1371/journal.pone.0026639, 2011.
Chang, S.-E., Horwitz, B., Ostuni, J., Reynolds, R., Ludlow, C.L. Evidence of left inferior frontal-premotor structural and functional connectivity deficits in adults who stutter. Cerebral Cortex21: 2507-2518, 2011.
Rong, F., Holroyd, T., Husain, F.T Contreras-Vidal, J.L., Horwitz, B. Task-specific modulation of human auditory evoked response in a delayed-match-to-sample task. Fron. Psychol.: Aud. Cogn. Neurosci. 2: 85, doi: 10.3389/fpsyg.2011.00085, 2011.
Simonyan, K., Horwitz, B. Laryngeal motor cortex and voluntary control of laryngeal behaviors.The Neuroscientist 17: 197-208, 2011.
Husain, F.T., Medina, R.E., Davis, C.W., Szymko-Bennett, Y., Simonyan, K., Pajor, N.M., Horwitz, B. Neuroanatomical changes due to hearing loss and chronic tinnitus: A combined VBM and DTI study. Brain Research 1369: 74-88, 2011.
Kikuchi, Y., Horwitz, B., Mishkin, M. Hierarchical auditory processing directed rostrally along the monkey's supratemporal plane. J. Neuroscience 30: 13021-13030, 2010.
Smith, J.F., Pillai, A., Chen, K., Horwitz, B. Identification and validation of effective connectivity networks in functional magnetic resonance imaging using switching linear dynamic systems.Neuroimage 52: 1027-1040, 2010.
Smith, J.F., Alexander, G.E., Chen, K., Husain, F.T., Kim, J., Pajor, N., Horwitz, B. Imaging systems level consolidation of novel associate memories: A longitudinal neuroimaging study.Neuroimage 50: 826-836, 2010.
Simonyan, K., Ostuni, J., Ludlow, C.L., Horwitz, B. Functional but not structural networks of the human laryngeal motor cortex show left hemispheric lateralization during syllable but not breathing production. J. Neurosci. 29: 14912-14923, 2009.
Stoeckel, L.E., Kim, J., Weller, R.E., Cox, J.E., Cook, E.W., Horwitz, B. Effective connectivity of a reward network in obese women. Brain Res. Bull. 79: 388-395, 2009.
Husain, F.T., Patkin, D.J., Thai-Van, H., Braun, A.R., Horwitz, B. Distinguishing the processing of gestures from signs in deaf individuals: An fMRI study. Brain Research 1276: 140-150, 2009.
Papoutsi, M., de Zwart, J.A., Jansma, J.M. Pickering, M.J., Bednar, J.A., Horwitz, B. From phonemes to articulatory codes: An fMRI study of the role of Broca's area in speech production. Cerebral Cortex, 19: 2156-2165, 2009.
Rosenbaum, R.S., Furey, M.L., Horwitz, B., Grady, C.L. Altered connectivity among emotion-related brain regions during short-term memory in Alzheimer's Disease. Neurobiol. Aging 31: 780-786, 2010.
Kim, J., Horwitz, B. How well does Structural Equation Modeling reveal abnormal brain anatomical connections? An fMRI simulation study. Neuroimage 45: 1190-1198, 2009.
Marrelec, G., Kim, J., Doyon, J., Horwitz, B. Large scale neural model validation of partial correlation analysis for effective connectivity investigation in functional MRI. Human Brain Mapp., 30: 941-950, 2009.
Ulloa, A., Husain, F.T., Kemeny, S., Xu, J., Braun, A. R., Horwitz, B. Neural mechanisms of auditory discrimination of long-duration tonal patterns: A neural modeling and fMRI study. J. Integrative Neurosci. 7: 501-527, 2008.
Wen, S., Ulloa, A., Husain, F., Horwitz, B., Contreras-Vidal, J.L. Simulated neural dynamics of decision-making in an auditory delayed match-to-sample task. Biol. Cybernetics 99: 15-27, 2008.
Stephan, K.E., Riera, J. J., Deco, G., Horwitz, B. The Brain Connectivity Workshops: Moving the frontiers of computational systems neuroscience. Neuroimage 42: 1-9, 2008.
Kim, J., Horwitz, B. Investigating the neural basis of fMRI-based functional connectivity in a blocked design: Application to interregional correlations and psych-physiological interactions.Magnetic Resonance Imaging 26: 583-593, 2008.
Horwitz, B., Wise, R.J.S. PET research of language, in Handbook of the Neuroscience of Language, ed. by B. Stemmer and H. A. Whitaker, Academic Press, pp. 71-80, 2008.
Horwitz, B., Smith, J.F. A link between neuroscience and informatics: Large-scale modeling of memory processes. Methods 44: 338-347, 2008.

Last Updated Date:

April 17, 2019